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[2020/09/21] Associate Professor Wang of the NYMU Institute of Biochemistry and Molecular Biology has Discovered a Key Step in Cilia Regeneration

Associate Professor Wang of National Yang-Ming University Institute of Biochemistry and Molecular Biology

 

The “centriole-cilia complex” is an indispensable structure within the cell. Any structural or functional defect in this complex can cause ciliary lesions. However, its related molecular functions remain unknown, which has increased the difficulty when treating related clinical diseases. Associate Professor Wang of National Yang-Ming University Institute of Biochemistry and Molecular Biology has been systemically exploring the physiological functioning of the “centriole-cilia complex” using cross-field technology. Her in-depth research of ciliary lesions and her novel discoveries have won her the Ministry of Science and Technology “Ta-You Wu Memorial Award.”

 

One of the most important research results is the discovery of a key step in cilia regeneration. The team has discovered that, during the process of ciliary regeneration, the centriole protein CEP83 is phosphorylated by TTBK2. They have also verified the phosphorylation site involved, proving that the phosphorylation of CEP83 is a key step in ciliary regeneration.

 

In addition, Associated Professor Wang has also used CRISPR/Cas9 genetic editing to establish a series of cell lines with centriole protein loss of function. Using these cell lines, the team has analyzed the molecular mechanism that maintains centriole geometric structure and in parallel developed a new theory regarding centriole geometric structure and maintenance.

 

The “centriole cilia complex” under the microscope

 

The above findings are all important and novel discoveries in the “centriole-cilia complex” research field and have been published in a range of important international journals. The research results will be able to be applied in the future to various biomedical fields and are valuable assets that show Associated Professor Wang’s unique research creativity and abundant research energy.

 

Associate Professor Wang and Her Lab Members

 

 

 

 

 

 

 

 

 

 

 


 

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