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[2019/12/25] TVGH and NYMU Publishes Multiple Innovative Research and Development Results that are of Great Industrial Value

NYMU and TVGH held their second “Taipei Veterans General Hospital and National Yang-Ming University Research Results Joint Presentation”

 

National Yang-Ming University and Taipei Veterans General Hospital held their second “Taipei Veterans General Hospital and National Yang-Ming University Research Results Joint Presentation”, which showcased the research results of twelve professors, various doctors and two incubation center industries. The results included a noise reduction system for cochlear implants, new methods to combat drug resistant cancer, and a brain cell imaging analysis technique for neuronal developmental diseases. It is hoped that all of these will enter the industrial development phase and when taken together they demonstrate the strong capabilities of the TVGH and NYMU research teams.

 

NYMU is constantly innovating and researching in the biomedical field and has strong research potential. Furthermore, TVGH is committed to the development of innovative medical techniques in order to provide even more comprehensive medical care and improved clinical resources. The cooperation between the TVGH and NYMU research teams means that they continue to create innovative research results and develop market value for Taiwan's biotechnology industry. These joint presentations not only showcase the latest research results, but also promote cooperation and exchange between industry, academia and clinical research institutions.

 

(Left) Academia Sinica associate researcher Tsao, Assistant Lai from the NYMU Department of Biomedical Engineering and Director Li from Cheng Hsin General Hospital together came up with the first “noise reduction system for cochlear implants” that uses AI

 

According to a statistical report from the WHO, the number of individuals with hearing loss is increasing and when a hearing impairment is unable to be improved by a hearing aid, a cochlear implant is another important option. However, there is a dilemma that involves the interaction between increasing sound volume and eliminating background noise and this is in need of a solution. Assistant Professor Lai from the NYMU Department of Biomedical Engineering, Cheng Hsin General Hospital Department of Otolaryngology and Auditory Medical Center Director Li and Academia Sinica Research Center for Information Technology Innovation Associate Researcher Tsao have improved user listening quality in a noisy environment through the development of an environment-sensitive noise cancellation system involving AI. The results from clinical trials have shown that this system is able to significantly improve language comprehension of users in a noisy environment. This innovative technique not only received the “15th National Innovation Award”, but also received gold medal recognition at the 2019 Korean “Wic World Invention Innovation Contest.”

 

Professor Yang (Middle) and his lab developed a peptide compound capable of inhibiting the drug resistance often found with head and neck tumors and has obtained Taiwan and U.S. patents for this peptide this September

 

In response to the problem of drug resistance to target drugs in tumors, Professor Tsai from the NYMU Institute of Clinical Medicine investigated the molecular mechanism of drug resistance for drugs targeting head and neck tumors and then designed a peptide named “peptide 9” that is able to interfere with the interaction between lymphotoxin-β and various target drugs; the results was an inhibition of resistance to the target drug. The patent has been licensed to various companies involved in the development of peptide new drugs and is expected to bring benefit to many patients.

 

In addition, Taipei Veterans General Hospital Research Department Director Chiu and Associate Researcher Wang have also developed a polypeptide inhibitor that is able to stop of the interaction between stem cell gene MSI1 and the AGO2 protein. This has been proven to be effective in animal studies by reducing stem cell drug resistance.

 

Associate Professor Tsai’s team developed an image analysis method for neuronal degenerative disease and neuritis that has opened up new opportunities for the treatment of cerebral neurodevelopmental abnormalitie

 

NYMU Brain Research Center Associate Professor Tsai’s team, who have been targeting brain abnormalities, have found 33 potential genes that are associated with brain malformation, microcephaly and various neuronal developmental diseases; they have done this using a combination of imaging, physical dynamics and molecular biology. Furthermore, they have also developed a cell imaging analysis system for neuronal degenerative diseases and neuritis. This has opened up new opportunities for the treatment of cerebral neurodevelopmental abnormalities.

 

TVGH Therapeutical and Research Center of Musculoskeletal Tumor Director Wu’s team developed an “antifreeze agent for protecting biological tissue” that not only is better than conventional liquid nitrogen, but also lowers the risk of possible complications. The team used a range of basic research and clinical techniques and these innovations mean that TVGH is one of the few hospitals in Taiwan that specializes in treating bone tumors.

 

Director Lan from the TVGH Department of Otorhinolaryngology - Head and Neck Surgery and Professor Li of National Central University Institute of Materials Science and Technology jointly developed a new capture panel for circulating tumor cells named the “Si-based multi-level nanometer platform for detecting nasopharyngeal cancer circulating tumor cells and EBV DNA." This platform is able to detect nasopharyngeal carcinoma tumor cells in the blood circulation as well as assessing the presence of EBV DNA. The panel shows high sensitivity, and has a high possibility of clinical application value. The panel can be used as an evaluation index for nasopharyngeal cancer patients before and after treatment. This is the first system in the world that is able to serve a double function in terms of circulating tumor cell detection.

 

 

 

 

 

 

 

 


 

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