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[2014/08/19]Tsai-Chu Yeh Receives 2014 College Student Research Award from the Ministry of Science and Technology

[2014/08/19]

Tsai-Chu Yeh Receives 2014 College Student Research Award from the Ministry of Science and Technology

Tsai-Chu Yeh, an undergraduate student in the Department of Medicine, won 2014 College Student Research Award from the Ministry of Science and Technology. Ms. Yeh's report, entitled "Identification of Plasma Proteins and Cellular Proteins as Potential Disease Biomarkers for Breast Cancers through Two-Stage Gel Filtration Chromatographic Analyses", was produced to recapitulate her research work conducted under the supervision of Dr. Yeou-Guang Tsay, an Associate Professor in the Institute of Biochemistry & Molecular Biology.

Breast cancer is one of the most prevalent cancers in women worldwide, and early detection and early treatment has been proven to significantly improve the chance of cure and drastically reduce its mortality. At present, no blood test is good for early screening of this fetal disease.

Dr. Tsay's laboratory has discovered and characterized several protein fragments that are only present in the blood plasma from patients with certain early-stage cancers. Motivated by these discoveries, Ms. Yeh's present work addressed whether any complement protein fragments could also serve as long-sought biomarkers for early breast cancer.

Primarily using biochemical techniques such as liquid chromatography, immunochemistry and mass spectrometry, Ms. Ye identified a fragment from a particular complement protein only present in some breast cancer patients. Despite its small size in the blood stream, her results suggest that this fragment can resist the renal filtration likely through strong non-covalent linkages with other parts of the parent complement protein. Owing to potential proprietary values, the details of these structures cannot be further disclosed.

Ms. Yeh, also a student of the Physician Scientist Program, would like to express her deep appreciation for the long-term support by this NYMU program. According to Ms. Yeh, this program has committed enormous resources so as to encourage more medical students like her to get actively involved in scientific research.

Ms. Tsai-Chu Yeh (left) and Dr. Yeou-Guang Tsay

Ms. Tsai-Chu Yeh (left) and Dr. Yeou-Guang Tsay


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