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[2014/06/30] "New Pathological Classification of Lung Adenocarcinoma

[2014/06/30]

"New Pathological Classification of Lung Adenocarcinoma Predicts Recurrence and Survival" Press Conference

National Yang-Ming University (NYMU) and Taipei Veterans General Hospital (VGHTPE) lung cancer research team recently published significant research findings in a prestigious journal. NYMU and VGHTPE held a "New pathological classification of lung adenocarcinoma predicts recurrence and survival" press conference on June 17, 2014. The research team found that the new pathological classification of lung adenocarcinoma predicts recurrence and mortality of lung cancer patients after surgery. Patients with "micropapillary" or "solid" predominant subtypes of lung adenocarcinoma have the highest recurrence rate and mortality rate.

The members of NYMU-VGHTPE lung cancer research team include Professor Wen-Hu Hsu, Chief Yu-Chung Wu, Dr Jung-Jyh Hung (all thoracic surgeons at VGHTPE), and Professor Teh-Ying Chou (Chief of Division of Molecular Pathology at VGHTPE and Director of Institute of Clinical Medicine at NYMU). Histologic classification of 573 patients undergoing resection for lung adenocarcinoma at VGHTPE was determined according to the new classification system proposed by the International Association for Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS). The percentage of each histologic component (lepidic, acinar, papillary, micropapillary, and solid) was recorded. The predominant pattern was defined according to the histologic component with the greatest percentage.

Micropapillary- and solid-predominant adenocarcinomas had significantly higher percentage of mediastinal lymph nodes metastasis. The percentage of recurrence was significantly higher in micropapillary- and solid-predominant adenocarcinomas. Furthermore, micropapillary- and solid-predominant adenocarcinomas had a significantly higher possibility of developing initial extrathoracic-only recurrence than the other types. Micropapillary- or solid-predominant patterns had significant worse overall survival, probability of freedom from recurrence, and disease-specific survival than the other types in multivariable analysis. The results have been published in the "Journal of Clinical Oncology."

Professor Teh-Ying Chou, Director of Institute of Clinical Medicine of NYMU, said that lung cancer was the leading cause of cancer-related death in Taiwan. Tumor recurrence developed in 20%-30% of patients after surgical resection, and frequently led to death. These significant findings discovered by the joint efforts of NYMU-VGHTPE lung cancer research team are useful in stratifying high-risk patients for adjuvant chemoradiation therapy or close follow-up after the surgery.

 NYMU-VGHTPE lung cancer research team(right 2 is Professor Teh-Ying Chou)

NYMU-VGHTPE lung cancer research team(right 2 is Professor Teh-Ying Chou)


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