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[2014/05/02]Congratulations to Prof. Shih-Hwa Chiou for Winning the "102 Outstanding Research Award of National Science Council"

[2014/05/02]

Congratulations to Prof. Shih-Hwa Chiou for Winning the "102 Outstanding Research Award of National Science Council"

Prof. Shih-Hwa Chiou from the Department and Institute of Pharmacology won the "2013 Outstanding Research Award of National Science Counci". Dr. Chiou was awarded by his distinguished research on identifying recurrent factors and developing therapeutic methods for Glioblastoma multiform.

According to Dr.Chiou's research, these malignant phenomena of human cancers, such as the acquisition of drug-resistance during the course the therapeutic process, the continuity of cancer recurrence and metastasis, and the poor patient survival rate are closely related to cancer stem cells. It is of much urgency in clinical cancer treatment to precisely identify cancer stem cell-specific molecular mechanisms, and to develop novel therapies targeting cancer stem cells. Dr. Chiou previously developed an isolation technique to sort out stem cells or cancer stem cells and maintain them in in vitro culture. Using this platform, he has made a great advance in non-viral gene delivery system that presents promising efficiency and by delivery specific gene, it can target cancer stem cells to achieve a cell type-specific treatment.

Dr. Chiou has been devoted in identifying cancer stem cell-specific therapeutic targets, such as genes and microRNAs, as well as increasing the efficiency and bio-safety of therapeutic delivery methods. These would benefit a lot in clinical prognosis, and provide novel directions for translational medicine in anti-metastatic target therapy. Dr. Chiou also successfully established a crucial technique to regulate the self-renewal and pluripotency in stem cells, which provides a research platform for regeneration medicine, target therapy of cancer, and clinical research. He recently found that a protein called Parp1 is able to dramatically enhance the reprogramming efficiency and suppress the occurrence of stem cell-derived tumors. His finding has largely increased the safety of inducible pluripotent stem cell when applied in clinic.

These achievements of Dr. Chiou's group have been published in prestigious international scientific journal, Molecular Cell, and patents have been approved domestically and in USA.

 Prof. Shih-Hwa Chiou

Prof. Shih-Hwa Chiou


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