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[2014/03/03] Mr. Gitanjal Deka Receives the "JenLab Young Investigator Award"

[2014/03/03]

Mr. Gitanjal Deka Receives the "JenLab Young Investigator Award"

Mr. Gitanjal Deka, studying for his PhD at institute of Biophotonics of NYMU, is awarded the "JenLab Young Investigator Award" for the best paper presentation in the conference session, "Multiphoton Microscopy in the Biomedical Sciences XIV (BiOS Conf. 8948)", of the SPIE Photonics West held in Moscone Center, San Francisco, California, United States during 1-6 February 2014. SPIE Photonics West is the largest and most influential event for the laser and photonics community worldwide. The prestigious award was competed by young scholars internationally who are below 32 years old in age. The award provided Deka a diploma, a sum of US$2,000, and a tour to JenLab's workshop in Germany as an invited speaker.

"Deka's presentation is titled "Multiphoton microscopy for skin wound healing study in terms of cellular metabolism and collagen regeneration". This work, as a partial fulfilment of his Ph.D. pursuit, is under the supervision of Prof. Fu-Jen Kao in the institute of Biophotonics. The research interests focused on developing and applying multiphoton based laser scanning fluorescence and second harmonic (SH) microscopy. Note that fluorescence and the corresponding lifetime would report the interrogated molecule under a specific conformational state. Fluorescence lifetime characterizes the time a fluorophore spent at a higher excited state before returning to ground states by emitting fluorescence. Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to reflect the interaction of fluorophores with their immediate nano-environment.

Specifically, Deka and colleagues detect the relative concentration of NADH in bound and unbound states to characterize the relative metabolic activity of cells. NADH binds to metabolic enzymes to produce ATP in the process of glycolysis and the corresponding electron transport and exhibits different lifetimes depending on its state of binding, whereas SH signal would reflect the concentration of collagen. The FLIM and SH is used to monitor the physiology of wound healing in live rats noninvasively. The cellular metabolic activity and the collagen regeneration are tracked by NADH-FLIM and SH microscopy, respectively. In another set of experiment they also study the metabolic activity of migrating cancer cells in response to geometrical constrains. A novel in situ laser micro-fabrication technique was devised to induce the migration of cells through guided paths of different widths.

Prof. Fu-Jen Kao, Mr. Gitanjal Deka and Prof. Karsten König

Prof. Kao (left), Mr. Deka(middle) and Prof. Karsten König (CEO of the JenLab GmbH)


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