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[2013/12/31] Congratulations to Prof. Shih-Hwa Chiou on Winning the 9th3 Tien Te Lee Biomedical Award

[2013/12/31]

Congratulations to Prof. Shih-Hwa Chiou on Winning the 9th Tien Te Lee Biomedical Award

Prof. Shih-Hwa Chiou from the Department and Institute of Pharmacology has won the 9th Tien Te Lee Biomedical Young Scientist Award. It's an honor for Tien Te Lee Biomedical Foundation to give out awards, including the Outstanding Awards, Young Scientists Awards, and Distinguished Thesis Awards, to individuals who have made significant contributions on new medicines and human health improvements. Prof. Shih-Hwa Chiou was granted the Young Scientists Award for his excellent work on the investigation of iPS reprogramming and cancer stem cell self-renewal.

Prof. Chiou has established the crucial technique to induce successful cell reprogramming from somatic cells, and to retain the self-renewal and pluripotency of the reprogrammed cells. This technique provides an experimental and application platform for regeneration medicine as well as cancer target therapy. He found that several key stemness genes, such as Oct4, Sox2, Klf4, and c-Myc, not only maintain the stemness properties in normal stem cells but also increase the stemness properties in malignant tumors, resulting in the cancer recurrence, distal metastasis, and drug-resistance. Moreover, he also found that stemness genes usually play diverse roles between normal and cancer stem cells. His team recently demonstrated that Parp1 (poly ADP-ribose polymerase 1) is able to replace c-Myc and Klf4, two essential genes to induce cell reprogramming. The iPS derived from the reprogramming process with Parp1 replacing c-Myc and Klf4 presented reduced tumor formation incidence, and hence largely increases the safety of application and efficiency of generation of iPS. These results have been published in international medical research journal "Journal of Experimental Medicine".

Dr. Chiou has published many scientific papers about his research on stem cells in authoritative international journals, and also patented several of his inventions internationally. His breakthroughs on iPS and cell reprogramming were highly approved and recommended by the Nobel laureate of 2012, Dr. Shinya Yamanaka. This indicates international awareness of our domestic basic and stem cell researches, which is absolutely an encouragement for our society and research community.

  Prof. Shih-Hwa Chiou

Prof. Shih-Hwa Chiou


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