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[2013/07/29]Chia-Yu Kuo Receives the "Honorable Mention" Award of the Foundation of Taiwan Medical Development Awards for Outstanding Writings

Chia-Yu Kuo Receives the "Honorable Mention" Award of the Foundation of Taiwan Medical Development Awards for Outstanding Writings

[2013/07/29]

Chia-Yu Kuo Receives the "Honorable Mention" Award of the Foundation of Taiwan Medical Development Awards for Outstanding Writings

In the Foundation of Taiwan Medical Development Awards for Outstanding Writings in 2013, Chia-Yu Kuo, a 4th year undergraduate student in the Department of Medicine, received the "Honorable Mention" award. Chia-Yu's research paper, entitled "Intracellular viscoelasticity of HeLa cells during cell division studied by video particle-tracking microrheology", which won her this award, summarizes her research conducted under the supervision of Dr. Arthur Chiou, (Professor, Institute of Biophotonic).

On the biological problem addressed in her research, Chia-Yu briefly explained that cell division plays an important role in regulating cell proliferation and differentiation, which is managed by a complex sequence of cytoskeleton alteration that induces dividing cells to change their morphology to facilitate their division. The change in cytoskeleton structure is expected to affect the intracellular viscoelasticity, which may also contribute to cellular dynamic deformation during cell division. However, the intracellular viscoelasticity during cell division is not yet well understood.

In her study, 100-nm (diameter) polystyrene beads were injected into the cytoplasm of HeLa cells, and video particle tracking microrheology was applied to measure the intracellular viscoelasticity at different phases during cell division. The Brownian motion of the intracellular nanoprobes was analyzed to compute the viscoelasticity of HeLa cells in terms of the elastic modulus and viscous modulus. The experimental results indicate that during the course of cell division, both intracellular elasticity and viscosity increase in the transition from the metaphase to the anaphase, plausibly due to the remodeling of cytoskeleton and redistributions of molecular motors, but remain approximately the same from the anaphase to the telophase.

Immediately after hearing the news about the award, Chia-Yu could not wait to thank Professor Chiou and his lab members, especially Mr. Chen, Yin-Quan, a PhD student from the Institute of Biophotonics, who had guided her daily through out the course of her research. Chia-Yu noted, "Never would I have the opportunity to broaden the horizon in science without Professor Chiou's inspiration from the beginning to the very last minute, with constant encouragement, and the suggestion to submit a journal paper (which has been accepted for publication in the Journal of Biomedical Optics) and to participate in the competition. The team spirit and the harmonious atmosphere of the whole group are truly remarkable. Last, but not least, the step-and-step guidance by the PhD student, Chen, Yin-Quan, is indispensable for me to acquire the necessary skills to conduct the experiment and to prepare and deliver the oral presentation. What I have gained out of this research experience has far exceeded my original anticipation".

Miss Chia-Yu Kuo and his lab members

Miss Chia-Yu Kuo and his lab members


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