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[2013/01/15] Congratulation to Professor Shie-Liang, Edmond, Hsieh for Receiving the 8th TienTe Lee Biomedical Awards--Outstanding Awards
Congratulation to Professor Shie-Liang, Edmond, Hsieh for Receiving the 8th TienTe Lee Biomedical Awards--Outstanding Awards

[102/01/15]

Congratulation to Professor Shie-Liang, Edmond, Hsieh for Receiving the 8th TienTe Lee Biomedical Awards--Outstanding Awards

Professor Shie-Liang Hsieh, Director of the Institute of Clinical Medicine, receives a great honor, the 8th TienTe Lee Biomedical Awards--Outstanding Award- recently. This TienTe Lee Biomedical Awards are founded by the"TienTe Lee Biomedical Foundation", which was set up in memory of Mr. TienTe Lee, the founder of Yung-Shin Pharm. Ind. Co., Ltd. in 2005. The TienTe Lee Biomedical Foundation provides "Outstanding Awards", "Young Scientists Awards" and "Distinguished Thesis Awards" to honor the outstanding achievement of senior investigators, young investigators, and graduate students, respectively, with the hope to promote and encourage scientists to conduct high quality biomedical research in Taiwan each year. Due to the milestone discovery of "anti-CLEC5A monoclonal antibody as therapeutic agent to dengue hemorrhagic fever and Japanese encephalitis", Professor Hsieh wins the highest honor - the "Outstanding Awards".

Professor Hsieh is a distinguished molecular immunologist who cloned the cDNAs of C-type lectin receptors (CLRs) and other members of innate immunity receptors from dendritic cells, macrophages and other immune cells to produce recombinant proteins and develop a novel method "Innate immunity receptor enzyme-linked immunoassay, also known as (IIR-EIA)" to determine the polysaccharide profiling of Chinese herb drugs. This method allows the rapid identification of the major components of the complex glycans in herb drugs, and is crucial for the quality and quantity control of polysaccharides isolated from natural products. Thus, the IIR-EIA is invaluable to ensure the consistency of polysaccharides for the development of modern herb medicine.

In addition, Professor Hsieh applies the IIR-EIA to identify CLEC5A, a member of CLR family, as the critical receptor for the pathogenesis of flaviviral infections, including Dengue Virus, Japanese Encephalitis Virus, and West Nile Virus. Professor Hsieh further generated blocking antibody to inhibit flavivirus binding to CLEC5A, and prove its therapeutic effect to protect host from lethality in murine model systems. This discovery provides a novel approach to develop specific treatment against viral infections, and is offered the US patent for drug development already.

"The aims of our research are not only to answer fundamental biomedical questions, but also to provide novel therapeutic agents to diseased without effective treatment", Professor Hsieh said after receiving the honor. Currently, professor Hsieh is producing other CLR-deficient mice and novel antibodies to reveal the mysterious functions of CLRs in host-pathogen interaction, neuroinflammation, autoimmune disease and other aseptic inflammation commonly found in human diseases.

Prof. Hsieh receives the 8th TienTe Lee Biomedical Awards

Prof. Hsieh receives the 8th TienTe Lee Biomedical Awards--Outstanding Awards


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