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[2012/09/14] Professor Shie-Liang Edmond Hsieh receives National Chair Professorship Awards

[2012/09/14]

Professor Shie-Liang Edmond Hsieh receives National Chair Professorship Awards

The Ministry of Education announced the recipients of the 16th"National Chair Professorship Awards" on September 7, 2012. Dr. Shie-Laing Edmond Hsieh, Director of Institute of Clinical Medicine, is awarded this honor due to his excellent works to reveal "The role of CLEC5A in the pathogenesis of dengue hemorrhagic fever and Japanese encephalitis" and "The molecular mechanism of DcR3-mediated tumor growth and metastasis".

Dr. Hsieh devotes himself to cancer immunology research since he came back to Yang-Ming University in 1993. He is one of the pioneers to reveal the functions of members of TNF superfamily - LIGHT and decoy receptor 3 (DcR3) - in cell apoptosis and tumor growth. Professor Hsieh and his team members identify DcR3 as a critical biomarker to predict tumor progression and metastasis, and they further identify the underlying molecular mechanism of DcR3-mediated tumor growth. Recently, he participates actively in innate immunity research to understand how C-type lectin receptors recognize diverse antigens and cause inflammatory reactions. Professor Hsieh develops the "Innate Immunity Receptor Enzyme-linked Immunosorbent Assay (IIR-EIA)" to identifies CLEC5A as dengue virus receptor. They generate monoclonal antibody to prevent dengue virus-induced hemorrhagic shock and Japanese Encephalitis Virus-induced neuroinflammation. This discovery brings the hope to develop therapeutic antibody for the treatment of flaviviral infections.

Professor Hsieh gives lectures to introduce the importance of "innate immunity" and "glycoimmunology" in the pathogenesis of human diseases, and elucidate the critical roles of glycan-lectin interaction in the onset of many un-resolved acute and chronic inflammatory diseases, such as autoimmune diseases and hypersensitivity.

Professor Hsieh acknowledges the long-term supports from Yang-Ming University, VGH-Taipei, and Genomics Research Center, Academia Sinica in the past years. "Without the strong and zealous commitments, it would be impossible to overcome the difficulties encountered in the laboratory". Professor Hsieh is grateful to all the students, post-doctors and all the team members, and hopes their discovery will translate benchside promise into bedside reality in the future.

Professor Hsieh receives National Chair Professorship Awards.

Professor Shie-Liang Edmond Hsieh receives National Chair Professorship Awards.

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