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[2012/04/24] The Pharmacological Society in Taiwan----Prof. Chen-Yuan Lee Outstanding Research Award

The Pharmacological Society in Taiwan----Prof. Chen-Yuan Lee Outstanding Research Award

[101/04/24]

The Pharmacological Society in Taiwan----Prof. Chen-Yuan Lee Outstanding Research Award

Dr. Shih-Hwa Chiou, professor of the Institute of Pharmacology, was awarded the Prof. Chen-Yuan Lee Outstanding Research Award for his distinguished investigations on cancer therapies targeting tumor-initiating cells. The Prof. Chen-Yuan Lee Outstanding Research Award, administered by the Pharmacological Society in Taiwan, elects one prize winner each year out of numerous candidates through a strict reviewing process, aiming to encourage the climate and elevate the level of pharmacological research.

The malignant tumor is highly resistant to radiotherapy. Recent studies have ascribed the repopulation of the malignant tumor to a small subset of cancer cells which possess self-renewal capability and remain in an undifferentiated state, termed"umor-initiating cells (TICs)".TICs are closely connected to the therapeutic resistance, constantly recurrence, and metastatic incidence of cancer, and therefore correlated with low survival expectancy of cancer patients. The contemporary clinical treatments for cancer patients still fail to effectively and completely eliminate the TICs. It is in an urge need medical research to clarify TIC-specific molecular mechanisms and to develop effective TIC-targeted therapies.

Dr. Chiou has been devoted in the research and development of isolating stem cells and TICs, and has successfully purified TICs from different malignant tumor tissues. The method of TICs isolation and the established drug-screening platform using the isolated TICs have been patented in the USA (Appl. No: 12/501,279; Confirmation No. 4022) and in Taiwan (Patent NO: I 360576). Dr. Chiou further focused on the TIC-targeted therapies with gene delivery method; he has developed a non-virus vector-based system to deliver target genes with elevated efficiency.

Dr. Chiou also undertook a series of researches to dissect and improve the delivery efficiency and bio-safety of the therapeutic methods that transfer specific genes or microRNAs to target TICs precisely. His academic achievements have been published in international scientific journals including Gatroenterology, Cancer Research, Biomaterials, Clinical Cancer Research, Journal of Pathology, and Molecular Cancer Therapeutic, etc. These discoveries have brought great advantages on the diagnosis of cancer patients for clinical doctors, and provided new directions in further investigations of anti-metastatic therapies for translational medicine.

Dr. Chiou won the Prof. Chen-Yuan Lee Outstanding Research Award.

Dr.Chiou(right) won the Prof. Chen-Yuan Lee Outstanding Research Award.


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