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[2012/03/07] Congratulations on Dr. Kou-Juey Wu for winning the 2011 Outstanding Research Award of National Science Council

Congratulations on Dr. Kou-Juey Wu for winning the 2011 Outstanding Research Award of National Science Council

[101/03/07]

Congratulations on Dr. Kou-Juey Wu for winning the 2011 Outstanding Research Award of National Science Council

Congratulations on Dr. Kou-Juey Wu, a distinguished professor at the Inst. of Biochemistry & Mol. Biology, for winning the NSC outstanding research award. This is the second time that Dr. Wu wins the award. Dr. Wu's research career started in the US. During the period, Dr. Wu published papers on Science and Nature Genetics. The paper in Nature Genetics was cited more than 600 times (Google search result) since it discovered the important mechanism of Telomerase gene regulation by c-Myc.

After returning to Taiwan, Dr. Wu moved to the Inst. of Biochemistry & Mol. Biology at National Yang-Ming Univ. At first, Dr. Wu's lab focused on the mechanism of c-Myc mediated transformation and discovered a few c-Myc target genes (Hsp90, Hsp60, NBS1) which contributed to c-Myc-induced transformation. The results were published in J. Biol. Chemistry, Clinical Cancer Research, and Oncogene.

Important contributions:

1.The first important contribution from Dr. Wu's lab is the result which Dr. Wu showed that Twist, a master regulator of mesoderm development, is directly regulated by hypoxia/HIF-1alpha . This result elucidates the mechanism of hypoxia-induced cancer metastasis. The work was published in Nature Cell Biology (March, 2008). After its publication, the paper has been cited 197 times (Scopus citation). It has also been featured in the same issue of Nature Cell Biology.

2.The second important contribution from Dr. Wu's lab (in collaboration with the lab of Dr. Muh-Hwa Yang) is the work that Dr. Wu showed the regulation of Bmi1, a stemness related gene, by Twist1. These results demonstrate that Twist1, an EMT regulator, directly activates a stemness gene, Bmi1, to induce EMT as well as cancer stemness. This result elucidates the concept of co-existence of EMT and cancer stemness, providing the real mechanistic explanation. The results were also published in Nature Cell Biology (Oct. 2010). The paper was also a featured article in the same issue of Nature Cell Biology as well as introduced by another major journal, Nature Reviews Cancer. This paper is the representative work submitted in the NSC application.

Dr. Wu wants to thank Dr. Muh-Hwa Yang as well as students and postdocs in the lab, especially to Drs. Jung-Jyh Hung, Ya-Ping Tsai, and Han-Tsang Wu for their papers submitted in the NSC application. Dr. Wu great appreciates President Kung-Yee Liang and former President Yan-Hwa Wu Lee for their support. The efforts and awards provided by NSC to the scientific community in Taiwan are also greatly appreciated.

Dr. Kou-Juey Wu

Dr. Kou-Juey Wu


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